Simonetta, Giacomo, an Italian cardinal, was born at Milan about 1475, and after education at Padua and Pavia was made priest and went to Rome, where Julius I appointed him advocate consistorial in 1505, and later auditor of the Rota. Clement VII gave him the bishopric of Pesaro in 1529, and Paul III created him cardinal in 1535, giving him also the bishopric of Perugia as well as the administration of the dioceses of Lodi, Sutri, Nepi, and Conza. Simonetta died at Rome Nov. 1, 1539, having published only two treatises: De Reservutionibus Beneficiorumn (Cologne, 1583; Rome, 1588), and De Vita et Miraculis Francisci de Paula (ibid. 1625).
His younger brother, GIACOMO FILIPPO, likewise born at Milan, also became an ecclesiastic, and was provided with rich benefices. He wrote Epigrammata (Milan, s.d.) and other poems.